Interspecies Scaling of Antibody–Drug Conjugates (ADC) for the Prediction of Human Clearance

Interspecies Scaling of Antibody–Drug Conjugates (ADC) for the Prediction of Human Clearance

Allometric scaling is a useful tool for the extrapolation of pharmacokinetic parameters from animals to humans. The objective of this study was to predict human clearance of antibody–drug conjugates (ADC) allometrically from one to three animal species and compare the predicted human clearance with...

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Bibliographic Details
Main Author: Iftekhar Mahmood
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Antibodies
Subjects:
ADCs
allometric scaling
single and multiple-species scaling
pharmacokinetics
clearance
Online Access:https://www.mdpi.com/2073-4468/10/1/1

Internet

https://www.mdpi.com/2073-4468/10/1/1

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