Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma

Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma

Abstract Background Aldehyde dehydrogenase 1 family member A1 (RALDH1)-producing dermal dendritic cells (DCs), a conventional DC subset regulating skin fibrosis, are decreased in the involved skin of patients with systemic sclerosis (SSc). In this study, we investigated the contribution of Fli1 defi...

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Bibliographic Details
Main Authors: Shunsuke Miura, Yusuke Watanabe, Ryosuke Saigusa, Takashi Yamashita, Kouki Nakamura, Megumi Hirabayashi, Takuya Miyagawa, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato, Yoshihide Asano
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Arthritis Research & Therapy
Subjects:
Aldehyde dehydrogenase 1 family member A1
Dermal dendritic cells
Fli1
Regulatory T cells
Systemic sclerosis
Online Access:https://doi.org/10.1186/s13075-021-02520-z

Internet

https://doi.org/10.1186/s13075-021-02520-z

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