The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology. We thus generated mice with a specific knockout o...

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Bibliographic Details
Main Authors: Emilie Ronin, Martina Lubrano di Ricco, Romain Vallion, Jordane Divoux, Ho-Keun Kwon, Sylvie Grégoire, Davi Collares, Angéline Rouers, Véronique Baud, Christophe Benoist, Benoit L. Salomon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
NF-κB
autoimmunity
stability
activation
relA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02487/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02487/full

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