Statistical analysis of single-copy assays when some observations are zero

Statistical analysis of single-copy assays when some observations are zero

Observational and interventional studies for HIV cure research often use single-copy assays to quantify rare entities in blood or tissue samples. Statistical analysis of such measurements presents challenges due to tissue sampling variability and frequent findings of 0 copies in the sample analysed....

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Bibliographic Details
Main Authors: Peter Bacchetti, Ronald J. Bosch, Eileen P. Scully, Xutao Deng, Michael P. Busch, Steven G. Deeks, Sharon R. Lewin
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Journal of Virus Eradication
Subjects:
HIV
latent reservoir
rare entities
statistical bias
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664020300479

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http://www.sciencedirect.com/science/article/pii/S2055664020300479

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