Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins

Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems. nAChRs are involved in a range of physiological and pathological functions and hence are important thera...

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Bibliographic Details
Main Authors: Thao N. T. Ho, Nikita Abraham, Richard J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
nAChRs
allosteric inhibitors
natural products
venom peptides
conotoxins
snake toxins
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.609005/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.609005/full

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