Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice

Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice

Liver fibrosis is an abnormal wound healing response and a common consequence of chronic liver diseases from infection or alcohol/xenobiotic exposure. At the cellular level, liver fibrosis is mediated by trans-differentiation of hepatic stellate cells (HSCs), which is driven by persistent hepatic an...

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Bibliographic Details
Main Authors: Han Zheng, Yang You, Meiyun Hua, Pengfei Wu, Yu Liu, Zishuo Chen, Li Zhang, Haoche Wei, Yan Li, Mei Luo, Yilan Zeng, Yong Liu, Dong-Xia Luo, Jie Zhang, Min Feng, Richard Hu, Stephen J. Pandol, Yuan-Ping Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Physiology
Subjects:
sodium copper chlorophyllin
liver fibrosis
intestinal tissue barrier
gut microbiota dysbiosis
NF-κB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01671/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.01671/full

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