Inactivation of the Autolysis-Related Genes lrgB and yycI in Staphylococcus aureus Increases Cell Lysis-Dependent eDNA Release and Enhances Biofilm Development In Vitro and In Vivo.

Staphylococcus aureus ica-independent biofilms are multifactorial in nature, and various bacterial proteins have been associated with biofilm development, including fibronectin-binding proteins A and B, protein A, surface protein SasG, proteases, and some autolysins. The role of extracellular DNA (e...

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Main Authors: Cristiana Ossaille Beltrame, Marina Farrel Côrtes, Raquel Regina Bonelli, Ana Beatriz de Almeida Côrrea, Ana Maria Nunes Botelho, Marco Antônio Américo, Sérgio Eduardo Longo Fracalanzza, Agnes Marie Sá Figueiredo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4583396?pdf=render