Germline <i>CDH1</i> G212E Missense Variant: Combining Clinical, In Vitro and In Vivo Strategies to Unravel Disease Burden

Germline <i>CDH1</i> G212E Missense Variant: Combining Clinical, In Vitro and In Vivo Strategies to Unravel Disease Burden

E-cadherin, encoded by <i>CDH1</i>, is an essential molecule for epithelial homeostasis, whose loss or aberrant expression results in disturbed cell–cell adhesion, increased cell invasion and metastasis. Carriers of <i>CDH1</i> germline mutations have a high risk of developin...

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Bibliographic Details
Main Authors: Joana Figueiredo, Fátima Mercadillo, Soraia Melo, Alicia Barroso, Margarida Gonçalves, José Díaz-Tasende, Patrícia Carneiro, Luis Robles, Francisco Colina, Carolina Ibarrola, José Perea, Eurico Morais-de-Sá, Raquel Seruca, Miguel Urioste
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
HDGC
E-cadherin
<i>CDH1</i> missense variant
functional assays
Online Access:https://www.mdpi.com/2072-6694/13/17/4359

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https://www.mdpi.com/2072-6694/13/17/4359

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