Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction

Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction

Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by progressive psychiatric, cognitive, and motor disturbances. We studied the expression of synaptic vesicle proteins in the R6/1 transgenic mouse model of HD. We observed that the levels of rabphilin 3A, a prote...

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Bibliographic Details
Main Authors: Ruben Smith, Åsa Petersén, Gillian P. Bates, Patrik Brundin, Jia-Yi Li
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
R6/1
Mouse
Synapse
Synaptic dysfunction
Exocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001361

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http://www.sciencedirect.com/science/article/pii/S0969996105001361

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