GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells.

GARP is regulated by miRNAs and controls latent TGF-β1 production by human regulatory T cells.

GARP is a transmembrane protein present on stimulated human regulatory T lymphocytes (Tregs), but not on other T lymphocytes (Th cells). It presents the latent form of TGF-β1 on the Treg surface. We report here that GARP favors the cleavage of the pro-TGF-β1 precursor and increases the amount of sec...

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Bibliographic Details
Main Authors: Emilie Gauthy, Julia Cuende, Julie Stockis, Caroline Huygens, Bernard Lethé, Jean-François Collet, Guido Bommer, Pierre G Coulie, Sophie Lucas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3787020?pdf=render

Internet

http://europepmc.org/articles/PMC3787020?pdf=render

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