Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

Overactive bladder (OAB) is the most bothersome symptom in lower urinary tract symptoms (LUTS). Current pharmacologic treatment aims to inhibit detrusor contraction; however, shows unsatisfied efficacy and high discontinuation rate. LIM kinases (LIMKs) promote smooth muscle contraction in the prosta...

Full description

Bibliographic Details
Main Authors: Qingfeng Yu, Chengjie Wu, Yeda Chen, Bingsheng Li, Ruixiao Wang, Ru Huang, Xuechun Li, Di Gu, Xiaolong Wang, Xiaolu Duan, Shujue Li, Yang Liu, Wenqi Wu, Martin Hennenberg, Guohua Zeng
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
LIMK
Cofilin phosphorylation
Overactive bladder (OAB)
Lower urinary tract symptoms (LUTS)
Bladder smooth muscle contraction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000046

Internet

http://www.sciencedirect.com/science/article/pii/S2211383521000046

Similar Items