Add-on Pyridostigmine Enhances CD4+ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study

Add-on Pyridostigmine Enhances CD4+ T-Cell Recovery in HIV-1-Infected Immunological Non-Responders: A Proof-of-Concept Study

BackgroundIn human immunodeficiency virus (HIV)-infection, persistent T-cell activation leads to rapid turnover and increased cell death, leading to immune exhaustion and increased susceptibility to opportunistic infections. Stimulation of the vagus nerve increases acetylcholine (ACh) release and mo...

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Bibliographic Details
Main Authors: Sergio I. Valdés-Ferrer, José C. Crispín, Pablo F. Belaunzarán-Zamudio, Carlos A. Rodríguez-Osorio, Bernardo Cacho-Díaz, Jorge Alcocer-Varela, Carlos Cantú-Brito, Juan Sierra-Madero
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
HIV
pyridostigmine
CD4+ T-cell
immune reconstitution
cholinergic anti-inflammatory pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01301/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01301/full

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