Inhibiting tumor necrosis factor‐alpha at time of induced intervertebral disc injury limits long‐term pain and degeneration in a rat model

Inhibiting tumor necrosis factor‐alpha at time of induced intervertebral disc injury limits long‐term pain and degeneration in a rat model

Background Painful intervertebral disc (IVD) degeneration has tremendous societal costs and few effective therapies. Intradiscal tumor necrosis factor‐alpha (TNFα) is commonly associated with low back pain, but the direct relationship remains unclear. Purpose Treatment strategies for low back pain r...

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Bibliographic Details
Main Authors: Thomas W. Evashwick‐Rogler, Alon Lai, Hironobu Watanabe, Jonathan M. Salandra, Beth A. Winkelstein, Samuel K. Cho, Andrew C. Hecht, James C. Iatridis
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:JOR Spine
Subjects:
axial back pain
discogenic pain
disc height
infliximab
intervertebral disc degeneration
low back pain
Online Access:https://doi.org/10.1002/jsp2.1014

Internet

https://doi.org/10.1002/jsp2.1014

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