Dendrogenin A synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

Dendrogenin A synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo

Dendrogenin A (DDA) is a mammalian cholesterol metabolite that displays potent antitumor properties on acute myeloid leukemia (AML). DDA triggers lethal autophagy in cancer cells through a biased activation of the oxysterol receptor LXRβ, and the inhibition of a sterol isomerase. We hypothesize that...

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Bibliographic Details
Main Authors: Nizar Serhan, Pierre-Luc Mouchel, Philippe de Medina, Gregory Segala, Aurélie Mougel, Estelle Saland, Arnaud Rives, Antonin Lamaziere, Gaëtan Despres, Jean-Emmanuel Sarry, Clément Larrue, François Vergez, Laetitia Largeaud, Michel Record, Christian Récher, Sandrine Silvente-Poirot, Marc Poirot
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
Acute myeloid leukemia
Dendrogenin A
tumor suppressor
cholesterol metabolism
synergy
primary cancer cells
Online Access:https://www.mdpi.com/2072-6694/12/7/1725

Internet

https://www.mdpi.com/2072-6694/12/7/1725

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