Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice

Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice

Abstract The maintenance of mitochondrial activity in hypothalamic neurons is determinant to the control of energy homeostasis in mammals. Disturbs in the mitochondrial proteostasis can trigger the mitonuclear imbalance and mitochondrial unfolded protein response (UPRmt) to guarantee the mitochondri...

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Bibliographic Details
Main Authors: Renata R. Braga, Barbara M. Crisol, Rafael S. Brícola, Marcella R. Sant’ana, Susana C. B. R. Nakandakari, Suleyma O. Costa, Patrícia O. Prada, Adelino S. R. da Silva, Leandro P. Moura, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-82352-8

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https://doi.org/10.1038/s41598-021-82352-8

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