Phosphorylation at Ser26 in the ATP-binding site of Ca2+/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity

Phosphorylation at Ser26 in the ATP-binding site of Ca2+/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity

CaMKII (Ca2+/calmodulin-dependent kinase II) is a serine/threonine phosphotransferase that is capable of long-term retention of activity due to autophosphorylation at a specific threonine residue within each subunit of its oligomeric structure. The γ isoform of CaMKII is a significant reg...

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Bibliographic Details
Main Authors: Mehtap Yilmaz, Samudra S. Gangopadhyay, Paul Leavis, Zenon Grabarek, Kathleen G. Morgan
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-02-01
Series:Bioscience Reports
Subjects:
activity switch
Ca2+/calmodulin-dependent kinase II (CaMKII)
CaMKII γ
phosphorylation
serine/threonine protein kinase
Online Access:http://www.bioscirep.org/bsr/033/e024/bsr033e024.htm

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http://www.bioscirep.org/bsr/033/e024/bsr033e024.htm

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