Oral Bioavailability and Plasma Disposition of Pefloxacin in Healthy Broiler Chickens

Oral Bioavailability and Plasma Disposition of Pefloxacin in Healthy Broiler Chickens

The pharmacokinetics of pefloxacin after single 10 mg/kg BW intravenous (IV) and oral doses were studied in healthy broiler chickens. For 24 h, serial blood samples were obtained after IV and oral administration. Concentrations of pefloxacin and its major metabolite N-demethyl pefloxacin (norfloxaci...

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Bibliographic Details
Main Authors: María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, María-Rosa Martínez-Larrañaga, Gerardo Isea, Arturo Anadón
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Veterinary Science
Subjects:
pefloxacin
broiler chickens
IV and oral dose
kinetics
PK/PD modeling
Online Access:http://journal.frontiersin.org/article/10.3389/fvets.2017.00077/full

Internet

http://journal.frontiersin.org/article/10.3389/fvets.2017.00077/full

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