Aminoglycoside stress together with the 12S rRNA 1494C>T mutation leads to mitophagy.

Aminoglycoside stress together with the 12S rRNA 1494C>T mutation leads to mitophagy.

Aminoglycosides as modifying factors modulated the phenotypic manifestation of mitochondrial rRNA mutations and the incomplete penetrance of hearing loss. In this report, using cybrids harboring the m.1494C>T mutation, we showed that gentamycin aggravated mitochondrial dysfunction in a combinatio...

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Bibliographic Details
Main Authors: Jialing Yu, Jing Zheng, Xiaoxu Zhao, Junxia Liu, Zhuochao Mao, Yining Ling, Danni Chen, Chao Chen, Lanlan Hui, Limei Cui, Ye Chen, Pingping Jiang, Min-Xin Guan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4256443?pdf=render

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http://europepmc.org/articles/PMC4256443?pdf=render

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