A micro-XRT image analysis and machine learning methodology for the characterisation of multi-particulate capsule formulations

A micro-XRT image analysis and machine learning methodology for the characterisation of multi-particulate capsule formulations

The application of X-ray microtomography for quantitative structural analysis of pharmaceutical multi-particulate systems was demonstrated for commercial capsules, each containing approximately 300 formulated ibuprofen pellets. The implementation of a marker-supported watershed transformation enable...

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Bibliographic Details
Main Authors: Frederik J.S. Doerr, Alastair J. Florence
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Pharmaceutical formulation
Micro-XRT particle analysis
Watershed image segmentation
Sensitivity analysis
Feature selection
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156720300013

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http://www.sciencedirect.com/science/article/pii/S2590156720300013

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