Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia

Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia

Administration of epidermal growth factor receptor (EGFR) inhibitors (e.g. AG1478/PD168393) promotes central nervous system (CNS) axon regeneration in vivo by an unknown mechanism. Here, we show that EGFR activation is not required for AG1478-/PD168393-induced neurite outgrowth in cultures of dorsal...

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Bibliographic Details
Main Authors: Zubair Ahmed, Steven J. Jacques, Martin Berry, Ann Logan
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Neurobiology of Disease
Subjects:
EGFR
AG1478/PD168393
Inhibitory CNS myelin
Glia
Neurotrophins
DRGN
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001764

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http://www.sciencedirect.com/science/article/pii/S0969996109001764

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