Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.

Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.

Steady-state metabolite concentrations in a microorganism typically span several orders of magnitude. The underlying principles governing these concentrations remain poorly understood. Here, we hypothesize that observed variation can be explained in terms of a compromise between factors that favor m...

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Bibliographic Details
Main Authors: Naama Tepper, Elad Noor, Daniel Amador-Noguez, Hulda S Haraldsdóttir, Ron Milo, Josh Rabinowitz, Wolfram Liebermeister, Tomer Shlomi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3784570?pdf=render

Internet

http://europepmc.org/articles/PMC3784570?pdf=render

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