CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft m...

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Bibliographic Details
Main Authors: Lennart Lenk, Michela Carlet, Fotini Vogiatzi, Lea Spory, Dorothee Winterberg, Antony Cousins, Michaela Vossen-Gajcy, Olta Ibruli, Christian Vokuhl, Gunnar Cario, Omar El Ayoubi, Lisa Kramer, Matthias Ritgen, Monika Brüggemann, Robert Häsler, Martin Schrappe, Stephan Fuhrmann, Christina Halsey, Irmela Jeremias, Elias Hobeika, Hassan Jumaa, Ameera Alsadeq, Denis M. Schewe
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01591-z

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https://doi.org/10.1038/s42003-020-01591-z

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