Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway

Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway

Abstract Background Cancer stem cell (CSC)-related chemoresistance leads to poor outcome of the patients with colorectal cancer (CRC). In this study, we identified the chemoresistance-relevant molecules and decipher the involved mechanisms to provide potential therapeutic target for CRC. We focused...

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Bibliographic Details
Main Authors: Xiaofeng Liu, Kunqi Su, Xiaoyan Sun, Yang Jiang, Lijun Wang, Chenyu Hu, Chunfeng Zhang, Min Lu, Xiaojuan Du, Baocai Xing
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Sec62
Chemosensitivity
Cancer stem cell
CRC
Wnt/β-catenin signaling
m6A modification
Online Access:https://doi.org/10.1186/s13046-021-01934-6

Internet

https://doi.org/10.1186/s13046-021-01934-6

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