Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) pathology. We searched for a pre-approved drug that suppresses abnormally activated Wnt/β-catenin signaling and has a potency to reduce joint pathology in OA. We introduced the TOPFlash reporter plasmid into...

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Bibliographic Details
Main Authors: Kentaro Miyamoto, Bisei Ohkawara, Mikako Ito, Akio Masuda, Akihiro Hirakawa, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Naoki Ishiguro, Kinji Ohno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5604944?pdf=render

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http://europepmc.org/articles/PMC5604944?pdf=render

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