Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production

Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production

We report the frequent, convergent loss of two genes encoding the substrate-binding protein and the ATP-binding protein of an ATP-binding cassette (ABC) transporter from the genomes of unrelated Clostridioides difficile strains. This specific genomic deletion was strongly associated with the reduced...

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Bibliographic Details
Main Authors: Matthias Steglich, Julia D. Hofmann, Julia Helmecke, Johannes Sikorski, Cathrin Spröer, Thomas Riedel, Boyke Bunk, Jörg Overmann, Meina Neumann-Schaal, Ulrich Nübel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Subjects:
Clostridium difficile
genome stability
repetitive DNA
transporter specificity
metabolism
metabolome
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00901/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00901/full

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