The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development

Summary: Regulatory T cells (Tregs) represent a major population in the control of immune homeostasis and autoimmunity. Here we show that Fos-like 2 (Fosl2), a TCR-induced AP1 transcription factor, represses Treg development and controls autoimmunity. Mice overexpressing Fosl2 (Fosl2tg) indeed show...

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Bibliographic Details
Main Authors: Florian Renoux, Mara Stellato, Claudia Haftmann, Alexander Vogetseder, Riyun Huang, Arun Subramaniam, Mike O. Becker, Przemyslaw Blyszczuk, Burkhard Becher, Jörg H.W. Distler, Gabriela Kania, Onur Boyman, Oliver Distler
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
immunology
autoimmunity
T cells
regulatory T cells
inflammation
mouse models
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472030807X

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http://www.sciencedirect.com/science/article/pii/S221112472030807X

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