Discovery & development of small molecule allosteric modulators of glycoprotein hormone receptors

Discovery & development of small molecule allosteric modulators of glycoprotein hormone receptors

Glycoprotein hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid stimulating hormone (TSH) are heterodimeric proteins with a common subunit and hormone-specific subunit. These hormones are dominant regulators of reproduction and metabolic processes. Receptors for...

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Bibliographic Details
Main Authors: Selvaraj G Nataraja, Henry N Yu, Stephen S Palmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Endocrinology
Subjects:
G-protein coupled receptor (GPCR)
Follicle stimulating hormone (FSH)
Thyroid stimulating hormone (TSH)
leucine rich repeat (LRR)
Glycoprotein hormone receptors
Small molecule allosteric modulators
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00142/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00142/full

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