Inhibitors of Lipoxygenase and Cyclooxygenase-2 Attenuate Trimethyltin-Induced Neurotoxicity through Regulating Oxidative Stress and Pro-Inflammatory Cytokines in Human Neuroblastoma SH-SY5Y Cells

Inhibitors of Lipoxygenase and Cyclooxygenase-2 Attenuate Trimethyltin-Induced Neurotoxicity through Regulating Oxidative Stress and Pro-Inflammatory Cytokines in Human Neuroblastoma SH-SY5Y Cells

Trimethyltin (TMT) is an environmental neurotoxin that mediates dopaminergic neuronal injury in the brain. In this study, we characterized the toxic mechanism and possible protective compounds against TMT-induced neurotoxicity in human dopaminergic neuroblastoma SH-SY5Y cells. Antioxidants such as m...

Full description

Bibliographic Details
Main Authors: Woo-Ju Song, Jang-Hyuk Yun, Myeong-Seon Jeong, Kil-Nam Kim, Taekyun Shin, Hyoung-Chun Kim, Myung-Bok Wie
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Brain Sciences
Subjects:
apoptosis
cyclooxygenase-2
esculetin
lipoxygenase
trimethyltin
Online Access:https://www.mdpi.com/2076-3425/11/9/1116

Internet

https://www.mdpi.com/2076-3425/11/9/1116

Similar Items