Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier[S]

Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier[S]

Cardiac triacylglycerol (TG) catabolism critically depends on the TG hydrolytic activity of adipose triglyceride lipase (ATGL). Perilipin 5 (Plin5) is expressed in cardiac muscle (CM) and has been shown to interact with ATGL and its coactivator comparative gene identification-58 (CGI-58). Furthermor...

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Bibliographic Details
Main Authors: Nina M. Pollak, Martina Schweiger, Doris Jaeger, Dagmar Kolb, Manju Kumari, Renate Schreiber, Stephanie Kolleritsch, Philipp Markolin, Gernot F. Grabner, Christoph Heier, Kathrin A. Zierler, Thomas Rülicke, Robert Zimmermann, Achim Lass, Rudolf Zechner, Guenter Haemmerle
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
adipose triglyceride lipase
cardiac lipid
energy metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422126

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http://www.sciencedirect.com/science/article/pii/S0022227520422126

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