The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction

Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that controls axonal expansion and contraction. Using s...

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Bibliographic Details
Main Authors: Ana Rita Costa, Sara C Sousa, Rita Pinto-Costa, José C Mateus, Cátia DF Lopes, Ana Catarina Costa, David Rosa, Diana Machado, Luis Pajuelo, Xuewei Wang, Feng-quan Zhou, António J Pereira, Paula Sampaio, Boris Y Rubinstein, Inês Mendes Pinto, Marko Lampe, Paulo Aguiar, Monica M Sousa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
actin ring
axonal cytoskeleton
axonal diameter
axonal electrophysiology
non-muscle myosin-ii
Online Access:https://elifesciences.org/articles/55471

Internet

https://elifesciences.org/articles/55471

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