Enhanced differentiation of isomeric RNA modifications by reducing the size of ions in ion mobility mass spectrometric measurements

Abstract With the ability to differentiate different molecular sizes, ion mobility spectrometry (IMS) has great potentials in the analysis of isomeric compounds. However, due to the lack of sensitivity and resolution, IMS has not been commonly used. To address the issue on resolution, the goals of t...

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Bibliographic Details
Main Authors: Hongzhou Wang, Daniel A. Todd, Norman H. L. Chiu
Format: Article
Language:English
Published: SpringerOpen 2020-10-01
Series:Journal of Analytical Science and Technology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40543-020-00243-5