Topography and motion of acid-sensing ion channel intracellular domains

Topography and motion of acid-sensing ion channel intracellular domains

Acid-sensing ion channels (ASICs) are trimeric cation-selective channels activated by decreases in extracellular pH. The intracellular N and C terminal tails of ASIC1 influence channel gating, trafficking, and signaling in ischemic cell death. Despite several X-ray and cryo-EM structures of the extr...

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Bibliographic Details
Main Authors: Tyler Couch, Kyle Berger, Dana L Kneisley, Tyler W McCullock, Paul Kammermeier, David M Maclean
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
ASIC
FRET
patch clamp fluorometry
DPA
fluorescence
gating
Online Access:https://elifesciences.org/articles/68955

Internet

https://elifesciences.org/articles/68955

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