Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
The host damage-response framework states that microbial pathogenesis is a product of microbial virulence factors and collateral damage from host immune responses. Immune-mediated host damage is particularly important within the size-restricted central nervous system (CNS), where immune responses ma...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2016-03-01
|
Series: | mBio |
Online Access: | http://mbio.asm.org/cgi/content/full/7/1/e01906-15 |
id |
doaj-4613b92f0c924b8592662f791b31ba4c |
---|---|
record_format |
Article |
spelling |
doaj-4613b92f0c924b8592662f791b31ba4c2021-07-02T04:43:08ZengAmerican Society for MicrobiologymBio2150-75112016-03-0171e01906-1510.1128/mBio.01906-15Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System InfectionsAnil A. PanackalKim C. WilliamsonDiederik van de BeekDavid R. BoulwarePeter R. WilliamsonThe host damage-response framework states that microbial pathogenesis is a product of microbial virulence factors and collateral damage from host immune responses. Immune-mediated host damage is particularly important within the size-restricted central nervous system (CNS), where immune responses may exacerbate cerebral edema and neurological damage, leading to coma and death. In this review, we compare human host and therapeutic responses in representative nonviral generalized CNS infections that induce archetypal host damage responses: cryptococcal menigoencephalitis and tuberculous meningitis in HIV-infected and non-HIV-infected patients, pneumococcal meningitis, and cerebral malaria. Consideration of the underlying patterns of host responses provides critical insights into host damage and may suggest tailored adjunctive therapeutics to improve disease outcome.http://mbio.asm.org/cgi/content/full/7/1/e01906-15 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anil A. Panackal Kim C. Williamson Diederik van de Beek David R. Boulware Peter R. Williamson |
spellingShingle |
Anil A. Panackal Kim C. Williamson Diederik van de Beek David R. Boulware Peter R. Williamson Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections mBio |
author_facet |
Anil A. Panackal Kim C. Williamson Diederik van de Beek David R. Boulware Peter R. Williamson |
author_sort |
Anil A. Panackal |
title |
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections |
title_short |
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections |
title_full |
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections |
title_fullStr |
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections |
title_full_unstemmed |
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections |
title_sort |
fighting the monster: applying the host damage framework to human central nervous system infections |
publisher |
American Society for Microbiology |
series |
mBio |
issn |
2150-7511 |
publishDate |
2016-03-01 |
description |
The host damage-response framework states that microbial pathogenesis is a product of microbial virulence factors and collateral damage from host immune responses. Immune-mediated host damage is particularly important within the size-restricted central nervous system (CNS), where immune responses may exacerbate cerebral edema and neurological damage, leading to coma and death. In this review, we compare human host and therapeutic responses in representative nonviral generalized CNS infections that induce archetypal host damage responses: cryptococcal menigoencephalitis and tuberculous meningitis in HIV-infected and non-HIV-infected patients, pneumococcal meningitis, and cerebral malaria. Consideration of the underlying patterns of host responses provides critical insights into host damage and may suggest tailored adjunctive therapeutics to improve disease outcome. |
url |
http://mbio.asm.org/cgi/content/full/7/1/e01906-15 |
work_keys_str_mv |
AT anilapanackal fightingthemonsterapplyingthehostdamageframeworktohumancentralnervoussysteminfections AT kimcwilliamson fightingthemonsterapplyingthehostdamageframeworktohumancentralnervoussysteminfections AT diederikvandebeek fightingthemonsterapplyingthehostdamageframeworktohumancentralnervoussysteminfections AT davidrboulware fightingthemonsterapplyingthehostdamageframeworktohumancentralnervoussysteminfections AT peterrwilliamson fightingthemonsterapplyingthehostdamageframeworktohumancentralnervoussysteminfections |
_version_ |
1721339644124069888 |