Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes

Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes

Acute inflammation often contributes to the increased arrhythmogenesis in the cardiomyocytes. We investigated the protective effects of pravastatin on calcium disorders induced by acute administration of pro-inflammatory cytokines in isolated ventricular myocytes and its underlying mechanisms. Wild-...

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Bibliographic Details
Main Authors: Song Zuo, Linling Li, Le Jiang, Chao Jiang, Xin Li, Songnan Li, Songnan Wen, Rong Bai, Xin Du, Jianzeng Dong, Nian Liu, Yanfei Ruan, Changsheng Ma
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Pharmacological Sciences
Subjects:
Pravastatin
Interleukin-6
Calcium handling
Reactive oxygen species
Acute inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300232

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http://www.sciencedirect.com/science/article/pii/S1347861320300232

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