Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.

Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.

Tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and induced by high glucose (HG) in human proximal tubular epithelial cells (PTEC). Since the kallikrein-kinin system (KKS) has been linked to cellular inflammatory process in many diseases, it is likely that KLK1 ex...

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Bibliographic Details
Main Authors: Wai Han Yiu, Dickson W L Wong, Loretta Y Y Chan, Joseph C K Leung, Kwok Wah Chan, Hui Yao Lan, Kar Neng Lai, Sydney C W Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3931644?pdf=render

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http://europepmc.org/articles/PMC3931644?pdf=render

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