Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses

Inhibitors of Apoptosis Protein Antagonists (Smac Mimetic Compounds) Control Polarization of Macrophages during Microbial Challenge and Sterile Inflammatory Responses

Apoptosis is a physiological cell death process essential for development, tissue homeostasis, and for immune defense of multicellular animals. Inhibitors of apoptosis proteins (IAPs) regulate apoptosis in response to various cellular assaults. Using both genetic and pharmacological approaches we de...

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Bibliographic Details
Main Authors: Vinod Nadella, Aparna Mohanty, Lalita Sharma, Sailu Yellaboina, Hans-Joachim Mollenkopf, Varadendra Balaji Mazumdar, Ramesh Palaparthi, Madhavi B. Mylavarapu, Radheshyam Maurya, Sreenivasulu Kurukuti, Thomas Rudel, Hridayesh Prakash
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
apoptosis
macrophages immunobiology
inflammation mediators
polarization
infection
hypothalamus
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01792/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01792/full

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