Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways

Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways

Abstract Multiple myeloma (MM) is a malignant tumor of transformed plasma cells. MM pathogenesis is a multistep process. This cancer can occur de novo (rarely) or it can develop from monoclonal gammopathy of undetermined significance (most of the cases). MM can be asymptomatic (smoldering myeloma) o...

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Bibliographic Details
Main Authors: Sabrina Manni, Marilena Carrino, Francesco Piazza
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Hematology & Oncology
Subjects:
Multiple myeloma
CK1
CK2
Bone marrow microenvironment
Survival signaling pathways
Non-oncogene addiction
Online Access:http://link.springer.com/article/10.1186/s13045-017-0529-5

Internet

http://link.springer.com/article/10.1186/s13045-017-0529-5

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