HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function.

HLA-Cw*0102-restricted HIV-1 p24 epitope variants can modulate the binding of the inhibitory KIR2DL2 receptor and primary NK cell function.

Accumulating evidence suggests an important role for Natural Killer (NK) cells in the control of HIV-1 infection. Recently, it was shown that NK cell-mediated immune pressure can result in the selection of HIV-1 escape mutations. A potential mechanism for this NK cell escape is the selection of HLA...

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Bibliographic Details
Main Authors: Lena Fadda, Christian Körner, Swati Kumar, Nienke H van Teijlingen, Alicja Piechocka-Trocha, Mary Carrington, Marcus Altfeld
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22807681/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22807681/?tool=EBI

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