A generic sample preparation approach for LC–MS/MS bioanalysis of therapeutic monoclonal antibodies in serum applied to Infliximab

A generic sample preparation approach for LC–MS/MS bioanalysis of therapeutic monoclonal antibodies in serum applied to Infliximab

In this study, we developed a generic bioanalytical workflow providing sensitive, specific, and accurate absolute quantification of therapeutic monoclonal antibodies in serum. The workflow involves magnetic beads coated with protein A to pull-down therapeutic monoclonal antibodies with affinity for...

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Bibliographic Details
Main Authors: Anne J. Kleinnijenhuis, Jan H. Toersche, Frédérique L. van Holthoon, Richard C. Bas, William D. van Dongen
Format: Article
Language:English
Published: Betasciencepress Publishers 2015-01-01
Series:Journal of Applied Bioanalysis
Subjects:
bioanalysis
monoclonal antibodies
LC-MS
infliximab
Online Access:http://dx.doi.org/10.17145/jab.15.005

Internet

http://dx.doi.org/10.17145/jab.15.005

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