Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells

Environmental Factor-Mediated Transgenerational Inheritance of Igf2r Hypomethylation and Pulmonary Allergic Response via Targeting Dendritic Cells

The developmental origin of allergic diseases has been suggested, but the molecular basis remains enigmatic. Exposure to environmental factors, such as di-(2-ethylhexyl) phthalate (DEHP; a common plasticizer), is suggested to be associated with increased childhood allergic asthma, but the causal rel...

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Bibliographic Details
Main Authors: Jau-Ling Suen, Tai-Ting Wu, Yue-Hyuan Li, Chin-Lai Lee, Fu-Chen Kuo, Pearlly S. Yan, Chia-Fang Wu, Mita Tran, Chien-Jen Wang, Chih-Hsing Hung, Ming-Tsang Wu, Michael W. Y. Chan, Shau-Ku Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
allergic inflammation
dendritic cell
di-(2-ethylhexyl) phthalate
insulin-like growth factor 2 receptor
trans-generation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.603831/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.603831/full

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