Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease

Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease

Profound alteration of the oxygen consumption rate (QO2) is present in the cervical spinal cord (CS) of the wobbler mice aged 12 weeks (wr12). Early symptomatic mice at 4 weeks (wr4) show less pronounced changes with decreases of basal QO2 (P < 0.03) and of QO2 through complex I (P < 0.04). Mi...

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Bibliographic Details
Main Authors: Barbara Santoro, Paolo Bigini, Giovanna Levandis, Vincenzo Nobile, Marco Biggiogera, Francesca Botti, Tiziana Mennini, Daniela Curti
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neurobiology of Disease
Subjects:
Motor neurons
Wobbler
Mitochondria
Complex I
Oxygen consumption
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001548

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http://www.sciencedirect.com/science/article/pii/S0969996104001548

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