PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (27-HOC) activates liver orphan receptor α (LX...

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Bibliographic Details
Main Authors: Tiangang Li, Wenling Chen, John Y.L. Chiang
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Journal of Lipid Research
Subjects:
bile acid synthesis
oxysterols
ATP binding cassette transporter A1
ATP binding cassette transporter G1
high density lipoprotein
liver orphan receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520436739

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http://www.sciencedirect.com/science/article/pii/S0022227520436739

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