Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis

Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis

Eosinophilic esophagitis (EoE) is an allergic disease of the esophagus driven by T cell and eosinophil responses to dietary allergens, resulting in chronic mucosal inflammation. Few spontaneous animal models of esophageal eosinophilia exist, with most studies relying on artificial sensitization proc...

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Bibliographic Details
Main Authors: Kristin Eden, Daniel E. Rothschild, Dylan K. McDaniel, Bettina Heid, Irving C. Allen
Format: Article
Language:English
Published: The Company of Biologists 2017-12-01
Series:Disease Models & Mechanisms
Subjects:
EoE
Eosinophils
Inflammation
TSLP
Gastrointestinal
NF-κB-inducing kinase
Online Access:http://dmm.biologists.org/content/10/12/1517

Internet

http://dmm.biologists.org/content/10/12/1517

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