Upregulated Interleukin 21 Receptor Enhances Proliferation and Epithelial-Mesenchymal Transition Process in Benign Prostatic Hyperplasia

Upregulated Interleukin 21 Receptor Enhances Proliferation and Epithelial-Mesenchymal Transition Process in Benign Prostatic Hyperplasia

Background: Interleukins (ILs) and related chronic inflammation have been found to contribute to the development of benign prostatic hyperplasia (BPH) in recent decades. As a late member of the ILs family, IL-21 receptor (IL-21R) can modulate cell proliferation, however, IL-21R activity in the prost...

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Bibliographic Details
Main Authors: Deqiang Xu, Ping Chen, He Xiao, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Endocrinology
Subjects:
benign prostatic hyperplasia
prostatitis
inflammation
interleukin 21 receptor
cell apoptosis
cell cycle
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00004/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00004/full

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