Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug

Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug

Abstract Background Proper blocking of toll-like receptor (TLR) activation during disease progression has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA). We tested whether the TLR4 inhibitor TAK-242 had potential as a remedy for rheumatoid arthritis. Methods...

Full description

Bibliographic Details
Main Authors: Snigdha Samarpita, Joo Young Kim, Mahaboob Khan Rasool, Kyoung Soo Kim
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Arthritis Research & Therapy
Subjects:
TLR4 inhibitor
TAK-242 (resatorvid)
Rheumatoid arthritis (RA)
Damage-associated molecular patterns (DAMPs)
Lipopolysaccharide (LPS)
Poly(I:C)
Online Access:https://doi.org/10.1186/s13075-020-2097-2

Internet

https://doi.org/10.1186/s13075-020-2097-2

Similar Items