LDL immune complexes stimulate LDL receptor expression in U937 histiocytes via extracellular signal-regulated kinase and AP-1

LDL immune complexes stimulate LDL receptor expression in U937 histiocytes via extracellular signal-regulated kinase and AP-1

We have previously shown that LDL-containing immune complexes (LDL-ICs) induce up-regulation of LDL receptor (LDLR) expression in human macrophages. The present study further investigated the molecular mechanisms leading to LDLR up-regulation by LDL-ICs as well as the signaling pathways involved. Re...

Full description

Bibliographic Details
Main Authors: Yuchang Fu, Yan Huang, Sumita Bandyopadhyay, Gabriel Virella, Maria F. Lopes-Virella
Format: Article
Language:English
Published: Elsevier 2003-07-01
Series:Journal of Lipid Research
Subjects:
low density lipoprotein
mitogen-activated protein kinase
activator protein
macrophages
signal transduction
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520310932

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520310932

Similar Items