Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.

Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.

Polarity coordinates cell movement, differentiation, proliferation and apoptosis to build and maintain complex epithelial tissues such as the mammary gland. Loss of polarity and the deregulation of these processes are critical events in malignant progression but precisely how and at which stage pola...

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Bibliographic Details
Main Authors: Nathan J Godde, Julie M Sheridan, Lorey K Smith, Helen B Pearson, Kara L Britt, Ryan C Galea, Laura L Yates, Jane E Visvader, Patrick O Humbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4031063?pdf=render

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http://europepmc.org/articles/PMC4031063?pdf=render

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