Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices

P-glycoprotein (ABCB1), an ATP-binding cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug–drug interactions. Drug-mediated induction of intestinal ABCB1 is a clinically relevant phenomenon associated with significantly decreased drug bioavailabil...

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Bibliographic Details
Main Authors: Ondrej Martinec, Carin Biel, Inge A. M. de Graaf, Martin Huliciak, Koert P. de Jong, Frantisek Staud, Filip Cecka, Peter Olinga, Ivan Vokral, Lukas Cerveny
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
induction
P-glycoprotein (ABCB1 protein)
human precision-cut intestinal slices
rifampicin
absorption
pregnane X receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.684156/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.684156/full

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