Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets

Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets

Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis. We show here that emperipolesis is a dynamic process mediated actively by both lineages, in part through the β2-integrin/ICAM-1/ezrin pathway. Tethered neutrophils enter in membrane-bound vesicles before penetrating...

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Bibliographic Details
Main Authors: Pierre Cunin, Rim Bouslama, Kellie R Machlus, Marta Martínez-Bonet, Pui Y Lee, Alexandra Wactor, Nathan Nelson-Maney, Allyn Morris, Li Guo, Andrew Weyrich, Martha Sola-Visner, Eric Boilard, Joseph E Italiano, Peter A Nigrovic
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
megakaryocyte
neutrophil
platelet
emperipolesis
membrane
Online Access:https://elifesciences.org/articles/44031

Internet

https://elifesciences.org/articles/44031

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