Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and Proinflammatory Activation of Macrophages
Background: <i>Trypanosoma cruzi (Tc)</i> causes Chagas disease (CD) that is the most frequent cause of heart failure in Latin America. TNF-α<sup>+</sup> monocytes/macrophages (Mo/Mφ) are associated with inflammatory pathology in chronic CD. In this study, w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-12-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/1/80 |